Types of Flea Pills for Dogs and some other facts you should know now
All oral flea prevention products have the potential to cause stomach upset, so they should be given with food. They should also be used with caution in dogs with seizure conditions, so check with your veterinarian first if you dog has a history of any neurologic problems.
Here’s a guide to the most common types of flea and tick pills for dogs.
Isoxazoline Class: Bravecto (fluralaner), NexGard (afoxolaner), Simparica (sarolaner), and Credelio (lotilaner)
The isoxazoline class of flea and tick pills for dogs is newer to the market and includes Bravecto, NexGard, Simparica, Simparica Trio, and Credelio. It has been a game-changer because these active ingredients are very effective against both fleas and ticks. Many of these products are also used off-label to treat and control certain types of mites that cause mange.
How They Work

The active ingredients in the isoxazoline class work on the nervous system of the flea, killing it once it bites your dog.
Are There Any Safety Risks?
Because the nervous systems of mammals do not have the same receptors as those of insects, these medications have a very low risk of toxicity and are very safe.
There have been some reported cases of adverse events such as seizures, but these are very rare and seem to mainly be an issue in dogs with pre-existing seizure conditions.
Spinosad (insecticide): Trifexis and Comfortis
Trifexis and Comfortis are flea pills for dogs that both use the active ingredient spinosad to kill fleas. Spinosad is an insecticide based on chemical compounds found in certain bacteria.
It is important to note that these products are solely flea pills for dogs and are ineffective against ticks.
How Spinosad Works
Spinosad targets the nervous system of insects. In fact, spinosad is often used by organic farmers to control insect problems.
Are There Any Safety Risks?
Spinosad is considered to be very safe.
Sentinel (lufenuron)
Sentinel is an insect-growth regulator, meaning that it prevents the hatching of flea eggs. Sentinel is not effective against ticks.
How Sentinel Works
Sentinel will not kill adult fleas, but instead prevents any future fleas from hatching, therefore controlling the flea infestation.
If your dog has an active flea infestation and is started on Sentinel for flea control, they may also need a product that kills adult fleas initially, like Capstar or Advantus.
Are There Any Safety Risks?
This product has been found to be very safe, but you should always consult your veterinarian if you are ever worried about the safety of a flea prevention product.
How Often Do You Need to Give Your Dog Flea and Tick Pills?
One thing to consider when you are weighing your options is the frequency of dosing. All of the above flea preventatives are given monthly, except for Bravecto, which is labeled for 12 weeks. It is important to note that this means it should be given every 12 weeks and not every three months, as some months have more days than others.
Some people like giving the flea and tick treatment every month along with heartworm preventative pills, because they find it easier to remember on a certain day of each month.
Other pet parents enjoy the fact that they don’t have to remember monthly dosing with Bravecto, although you will have to set a reminder every 12 weeks. The choice is yours; either way, it is recommended that you put a reminder on your calendar or in your phone so you’re never surprised with a flea infestation if you forget.
Do OTC Flea Pills Work as Well as Prescription Flea and Tick Pills?
Capstar (nitenpyram) and Advantus (imidacloprid) are both over-the-counter (OTC) products that kill adult fleas very quickly. They can be very useful in instances of severe flea infestations, when the adult fleas need to be killed quickly and safely.
While they work on flea infestations, they should not be used as your dog’s regular flea preventative, as they do not have lasting efficacy. Any flea larvae or eggs on your dog will still become adult fleas, and the infestation will start all over again.
If one of these products is used, it should be followed up with a prescription flea prevention product.
READ ALSO: How to teach your dog to accept a muzzle
Can You Use Natural Flea Preventatives?
Many people are curious about natural alternatives to flea pills for dogs. A simple internet search will show a multitude of claims about bathing pets with dish soap or using garlic, brewer’s yeast, essential oils, herbs, and other natural products.
While some of these products may have a small amount of efficacy against fleas, many of these are at best not very effective, and at worst downright dangerous.
For example, garlic is toxic to dogs and can even be fatal in large enough amounts, but many natural flea remedies recommend feeding it to your pet. Many essential oils can also be toxic, and most are not made to be applied directly to the skin.
As drugs, oral flea preventatives have been extensively tested and studied, and they are approved by the Food and Drug Administration. They are proven to be safe and effective, and they are closely monitored and regulated. Natural products have no such benefit of having safety and efficacy closely scrutinized.
Are Flea Pills Better Than Topical Flea Medications and Flea Collars?
While there is no single right or wrong answer when it comes to quality flea and tick prevention, some forms may work better than others for your particular dog.
Flea Pills for Dogs: Pros and Cons
The oral tablets are great for these reasons:
* Dogs generally enjoy them as a treat.
* You don’t have to worry about applying them incorrectly.
* There is no risk of the medication washing off as with topical products.
* They can’t break off and get lost like the collars could.
Here are some drawbacks to the flea pills:
* Your dog may refuse to eat the pill.
* You have to monitor your dog and make sure they eat the whole pill.
Topical Flea Treatments: Pros and Cons
As for the topical flea medications, they are tried and true. They have been used for decades, and most people are very familiar with them.
Contributed by Ellen Malmanger DVM